🩺 ANTI-PARKINSON DRUGS 🏷️ : MAO-B inhibitor
👨‍⚕️ Clinically Reviewed by: PakistaniBano Medical Editorial Board (Pharm.D Panel)
📅 Reviewed: November 2026 • 🔍 Authority: DRAP / WHO ATC
📦 Formulations, Pack Sizes & Retail Prices Currency: Rs.
Dosage Form Reg. No Pack Size Trade Price (TP) Maximum Retail Price (MRP)
Tab 0.5 mg — 10 Rs.171.93 Rs.202.28

📋 Indications & Clinical Dosage

*Parkinsons disease, used alone or as adjunct to cobeneldopaor co-careldopa for 'end-of-dose' fluctuations:* Adult: 1 mg daily if used as monotherapy, 0.5 mg if used as adjunct; increased to 1 mg if needed.

⚠️ Precautions & Warnings

Mild to moderate hepatic impairment, avoid abrupt withdrawal. Avoid in severe hepatic impairment

🔄 Drug Interactions

Other MAOls, St. Johns Wort, pethidine, fluoxetine, fluvoxamine, dextromethorphan, sympathomimetic amines, antidepressants.

⚠️ Adverse Reactions / Side Effects

Anorexia, arthralgia, abnormal dreams, angina, conjunctivitis, constipation, depression, dry mouth, dyspepsia, flatulence, hallucinations, headache, influenza-like symptoms, leucopenia, rash, rhinitis, skin carcinoma, urinary urgency, vertigo, weight loss. Rare: Cerebrovascular accident, myocardial infarction

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:
Use with caution
Lactation / Breastfeeding:
Caution advised

📚 Official Regulatory & Clinical References

  • Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
  • World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
  • Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

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