ADIFF (ADAPALENE, TOPICAL) Price

Dosage Form	Reg. No	Pack Size	Trade Price (TP)	Maximum Retail Price (MRP)
Gel 0.1%	—	15 gm	Rs.191.25	Rs.225.00
Gel 0.3%	—	15 gm	Rs.361.25	Rs.425.00

📋 Indications & Clinical Dosage

*Mild to moderate acne vulgaris:* Adults: Apply thin film once daily at bedtime after washing and drying the affected area.

⛔ Contraindications

Severe acne, broken skin, eczema, pregnancy (contraceptive must be used during after treatment)

⚠️ Precautions & Warnings

Avoid accumulation in angles of the nose, avoid contact with eyes, nostrils, mouth and mucous membranes, eczematous, broken or sunburned skin, avoid exposure to UV light, avoid in severe acne involving large areas, caution in sensitive areas such as the neck, lactation

🔄 Drug Interactions

Retinoids.

⚠️ Adverse Reactions / Side Effects

Local skin irritation; reduce application or withdraw if severe.

📚 Official Regulatory & Clinical References

Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.