📋 Indications & Clinical Dosage
*Replenishment of Extracellular Fluid (E.C.F.) to prevent reduced circulatory blood volume and interstitial fluid due to; trauma, scalds, burns and before, during and after surgery:*
BY IV DRIP INF: Adults: Usual adult dosage is 500-1000 ml at one time by IV drip INF at the rate of 300- 500 ml per hr (about 75-125 drops per min).
⛔ Contraindications
Lactacidaemia (lactic acidosis) with severe liver damage.
⚠️ Precautions & Warnings
Cardiac failure reduced urinary output due to obstructive urinary tract diseases, hypertonic dehydration, renal failure, alkalosis, lactic acid metabolism disturbances. Sodium Chloride content of this solution is 6.0 gm/litre. Therefore, care should be taken in those cases where salt intake is restricted as in oedema, hypertension etc.
⚠️ Adverse Reactions / Side Effects
Cerebral, pulmonary and peripheral oedema and dilution acidosis may occur with a large volume and/or acute infusion.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.