📋 Indications & Clinical Dosage
*Osmotic diuretic, for decompression in concussion and cerebral injury:*
BY IV INF: Adults: 50-200 gm in 24 hr. The rate of administration is usually adjusted to maintain a urine flow of at least 30 to 50 ml per hr.
⛔ Contraindications
Severe renal disease, dehydration, active intra cranial bleeding, severe pulmonary oedema.
⚠️ Precautions & Warnings
Cardio-vascular and renal status should be evaluated.
⚠️ Adverse Reactions / Side Effects
Congestive heart failure, headache, convulsions, dizziness, rash, electrolyte balance disturbances, hyponatraemia, GI disturbance, polyurea.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.