📋 Indications & Clinical Dosage
*Type 2 diabetes:*
Adults: Adult: Initially 30 mg daily with breakfast, adjust dose according to response every 4 wks (after 2 wks if no decrease in blood glucose); max 120 mg per day.
*Maturity-onset diabetes:*
Adults: Initially 40-80 mg daily with breakfast, adjusted according to response, increased if necessary up to 160 mg once daily, doses higher than 160mg to be given in divided doses; max 320 mg per day.
Children: Not recommended.
⛔ Contraindications
Acute porphyrias, insulin-dependent diabetes, diabetic ketoacidosis, pre-coma and coma, severe renal or hepaticin sufficiency.
⚠️ Precautions & Warnings
Children, avoid if the patient has both renal and hepatic impairment.
🔄 Drug Interactions
Miconazole, phenylbutazone, alcohol, insulin,
acarbose, biguanides, beta-blockers, fluconazole, ACE in
hibitors, H2 receptor antagonists, MAOls. sulphonamides, NSAIDs, danazol, chlorpromazine, glucocorticoids, ritodrine, salbutamol, terbutaline, anticoagulants.
⚠️ Adverse Reactions / Side Effects
Hypoglycaemia, dermatological reactions, GI disturbances, brain damage, dizziness.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated in pregnancy.
Lactation / Breastfeeding:
Caution advised, avoid.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.