Verified by DRAP 🩺 BLOOD GLUCOSE LOWERING DRUGS, EXCLUDING INSULIN 🏷️ Sulphonylurea
👨‍⚕️ Clinically Reviewed by: PakistaniBano Medical Editorial Board (Pharm.D Panel)
📅 Reviewed: November 2026 • 🔍 Authority: DRAP / WHO ATC
📦 Formulations, Pack Sizes & Retail Prices Currency: Rs.
Dosage Form Reg. No Pack Size Trade Price (TP) Maximum Retail Price (MRP)
MR Tab 30 mg 026977 2x10 Rs.338.06 Rs.397.72
MR Tab 60 mg 059974 2x10 Rs.488.57 Rs.571.26
Tab 80 mg 005332 2x10 Rs.202.18 Rs.237.86

📋 Indications & Clinical Dosage

*Type 2 diabetes:* Adults: Adult: Initially 30 mg daily with breakfast, adjust dose according to response every 4 wks (after 2 wks if no decrease in blood glucose); max 120 mg per day. *Maturity-onset diabetes:* Adults: Initially 40-80 mg daily with breakfast, adjusted according to response, increased if necessary up to 160 mg once daily, doses higher than 160mg to be given in divided doses; max 320 mg per day. Children: Not recommended.

⛔ Contraindications

Acute porphyrias, insulin-dependent diabetes, diabetic ketoacidosis, pre-coma and coma, severe renal or hepaticin sufficiency.

⚠️ Precautions & Warnings

Children, avoid if the patient has both renal and hepatic impairment.

🔄 Drug Interactions

Miconazole, phenylbutazone, alcohol, insulin, acarbose, biguanides, beta-blockers, fluconazole, ACE in hibitors, H2 receptor antagonists, MAOls. sulphonamides, NSAIDs, danazol, chlorpromazine, glucocorticoids, ritodrine, salbutamol, terbutaline, anticoagulants.

⚠️ Adverse Reactions / Side Effects

Hypoglycaemia, dermatological reactions, GI disturbances, brain damage, dizziness.

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:
Contraindicated in pregnancy.
Lactation / Breastfeeding:
Caution advised, avoid.

📚 Official Regulatory & Clinical References

  • Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
  • World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
  • Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.
  • Diamicron MR Tablets 30mg — DRAP Registration Number: 026977
  • Diamicron MR 60 Tablets — DRAP Registration Number: 059974
  • DIAMICRON TAB — DRAP Registration Number: 005332

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