🩺 OTHER BETA-LACTAM, CEPHALOSPORINS & PENEMS 🏷️ Antibacterials /Cephalosporins
👨‍⚕️ Clinically Reviewed by: PakistaniBano Medical Editorial Board (Pharm.D Panel)
📅 Reviewed: November 2026 • 🔍 Authority: DRAP / WHO ATC
📦 Formulations, Pack Sizes & Retail Prices Currency: Rs.
Dosage Form Reg. No Pack Size Trade Price (TP) Maximum Retail Price (MRP)
Cap 250 mg 030972 12 — Rs.450.50 530.00
Cap 500 mg 030973 12 — Rs.680.00 800.00
Drop 50 mg 030974 15 ml — Rs.163.20 192.00
Susp 125 mg 030975 60 ml — Rs.267.75 315.00
Susp 250 mg 030976 60 ml — Rs.488.75 575.00

📋 Indications & Clinical Dosage

*Susceptible infections due to sensitive Gram-positive and Gram-negative bacteria:* IMMEDIATE-RELEASE TAB: Adult: 250 mg 3 times a day; max. 4 g per day. Children 1-11 months: 20 mg/kg daily in 3 divided doses, alternatively 62.5 mg 3 times a day; 1-4 years: 20 mg/kg daily in 3 divided doses, alternatively 125 mg 3 times a day; Child 5-11 years: 20 mg/kg daily in 3 divided doses, usual max. 1 g daily, alternatively 250 mg 3 times a day; 12-17 years: same as adult. In severe infection: double the dose. SUSTAINED -RELEASE TAB: Adult & Children above 12 yrs: 375 mg every 12 hours, dose to be taken with food. *Pneumonia:* SUSTAINED -RELEASE TAB: Adult & Children above 12 yrs: 750 mg every 12 hours, dose to be taken with food. *Urinary-tract infections:* SUSTAINED-RELEASE TAB: Adult& Children above 12 yrs: 375 mg every 12 hours, dose to be taken with food. *Asymptomatic carriage of Haemophilus influenzae or mild exacerbations in cystic fibrosis:* IMMEDIATE-RELEASE TAB: Children 1-11 months: 125 mg every 8 hours;1-6 years: 250 mg 3 times a day; 7-17 years: 500 mg 3 times a day.

⚠️ Precautions & Warnings

Hypersensitivity, severe renal and hepatic impairment.

🔄 Drug Interactions

Anticoagulants, probenecid, antacids.

⚠️ Adverse Reactions / Side Effects

Abdominal discomfort, agranulocytosis, allergic reactions, anaphylaxis, aplastic anaemia, blood disorders, confusion, disturbances in liver enzymes, dizziness, eosinophilia, haemolytic anaemia, hallucinations, headache, hypertonia, leucopenia, nervousness, pruritus, rashes, fever and arthralgia, sleep disturbances, urticaria, GI disturbances, Rare: Stevens-Johnson syndrome, thrombocytopenia, toxic epidermal necrolysis, transient cholestatic jaundice, transient hepatitis,

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:
No evidence of harm
Lactation / Breastfeeding:
Caution advised

📚 Official Regulatory & Clinical References

  • Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
  • World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
  • Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

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