ACEF

*Susceptible infections due to sensitive Gram-positive and Gram-negative bacteria:* IMMEDIATE-RELEASE TAB: Adult: 250 mg 3 times a day; max. 4 g per day. Children 1-11 months: 20 mg/kg daily in 3 divided doses, alternatively 62.5 mg 3 times a day; 1-4 years: 20 mg/kg daily in 3 divided doses, alternatively 125 mg 3 times a day; Child 5-11 years: 20 mg/kg daily in 3 divided doses, usual max. 1 g daily, alternatively 250 mg 3 times a day; 12-17 years: same as adult. In severe infection: double the dose. SUSTAINED -RELEASE TAB: Adult & Children above 12 yrs: 375 mg every 12 hours, dose to be taken with food. *Pneumonia:* SUSTAINED -RELEASE TAB: Adult & Children above 12 yrs: 750 mg every 12 hours, dose to be taken with food. *Urinary-tract infections:* SUSTAINED-RELEASE TAB: Adult& Children above 12 yrs: 375 mg every 12 hours, dose to be taken with food. *Asymptomatic carriage of Haemophilus influenzae or mild exacerbations in cystic fibrosis:* IMMEDIATE-RELEASE TAB: Children 1-11 months: 125 mg every 8 hours;1-6 years: 250 mg 3 times a day; 7-17 years: 500 mg 3 times a day.

Hypersensitivity, severe renal and hepatic impairment.

Anticoagulants, probenecid, antacids.

Abdominal discomfort, agranulocytosis, allergic reactions, anaphylaxis, aplastic anaemia, blood disorders, confusion, disturbances in liver enzymes, dizziness, eosinophilia, haemolytic anaemia, hallucinations, headache, hypertonia, leucopenia, nervousness, pruritus, rashes, fever and arthralgia, sleep disturbances, urticaria, GI disturbances, Rare: Stevens-Johnson syndrome, thrombocytopenia, toxic epidermal necrolysis, transient cholestatic jaundice, transient hepatitis,