*Primary carnitine deficiency:*
Adults: 200 mg/kg daily in 2 - 4 divided doses; higher doses of up to 400 mg/ kg daily occasionally required; max: 3 gm daily.
*Secondary carnitine deficiency:*
Adults: 1 gm daily.
⚠️ Precautions & Warnings
Diabetes mellitus; monitoring of free and acylcarnitine in blood and urine recommended.
⚠️ Adverse Reactions / Side Effects
Nausea, vomiting, abdominal pain, diarrhoea, body odour ; side effect may be dose related; monitor tolerance during first week and after any dose increase.
📚 Official Regulatory & Clinical References
Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.
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