👨‍⚕️ Clinically Reviewed by: PakistaniBano Medical Editorial Board (Pharm.D Panel)
📅 Reviewed: November 2026 • 🔍 Authority: DRAP / WHO ATC
📦 Formulations, Pack Sizes & Retail Prices Currency: Rs.
Dosage Form Reg. No Pack Size Trade Price (TP) Maximum Retail Price (MRP)
Cap — 12 Rs.382.50 Rs.450.00
Powd — 10 Sachet Rs.680 Rs.800

📋 Indications & Clinical Dosage

*Acute and chronic diarrhoea, intestinal flora imbalance caused by antibiotics, chronic liver disease and dyspepsia:* Cap: Adults: 3 caps twice a day Sachet: 1 sachet twice or thrice a day; to be takenfor 3-7 days in acute diarrhoea, 14-21 days in chronic diarrhoea

⚠️ Precautions & Warnings

This medicine should not be taken with antibiotics.

🔄 Drug Interactions

Clostridium Butyricum is sensitive to ampicillin, cephazolin, tetracycline, chloromycetin, furazolidone. Bifidobacterium is sensitive to ampicillin, cefotaxime, chloromycetin, furazolidone and erythromycin.

⚠️ Adverse Reactions / Side Effects

Slight skin rash and sunlight discomfort.

📚 Official Regulatory & Clinical References

  • Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
  • World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
  • Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

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