📋 Indications & Clinical Dosage
*Combined active immunization of children against diphtheria, tetanus and pertussis:*
BY IM INJ: 3 doses of 0.5 ml injection at intervals of 4 week; fourth injection after3 to 12 months, is also recommended.
⛔ Contraindications
Hypersensitivity after previous administration of DPT vaccines, transient thrombocytopenia or neurological complications following an earlier immunisation against diphtheria and for tetanus, encephalopathy of unknown aetiology, occurring within 7 days following previous vaccination with pertussis containing vaccine.
⚠️ Precautions & Warnings
Acute severe febrile illness, history of any of the following events on previous vaccination with pertussis containing vaccine: fever within 48 hour, collapse or shock-like state within 48 hour, persistent & inconsolable crying lasting more than 3 hour occurring within 48 hour, convulsions within 3 days.
🔄 Drug Interactions
Immunosuppressive drugs.
⚠️ Adverse Reactions / Side Effects
Local pain, redness, swelling. Malaise, fatigue, headache, diarrhoea, irritability, loss of appetite, vomiting.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.