📋 Indications & Clinical Dosage
*Active immunization of healthy adults and adolescents found to be seronegative to varicella-zoster:*
BY SC INJ: Adults: 2 doses of 0.5 ml at dose interval of 8 week; minimum dose interval 6 wk.
Children above 1-2 y: who are in close contacts of persons at high risk of severe infection, 1 dose of 0.5ml.
⛔ Contraindications
Acute severe febrile illness, hypersensitivity, pregnancy; ensure adequate contraception during and for up to three months following course, lacta-tion, primary or acquired immune-deficiency
⚠️ Precautions & Warnings
Severe skin conditions. Signs of rash, advise to avoid contact with at risk individuals.
🔄 Drug Interactions
Do not give within three months of blood transfusion or immunoglobulins, salicylates during and for six weeks after course
⚠️ Adverse Reactions / Side Effects
Injection site reactions, fatigue, fever, headache, papulovesicular rash
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.