TRANOL

*Local fibrinolysis to prevent bleeding:* ORAL: Adults: 15-25 mg/kg body weight two-three times daily. BY SLOW IV INJ:0.5-1 gm slow IV injection 3 times daily. *Menorrhagia:* Adult: 1-1.5 gm 3-4 times daily, initiated when heavy bleeding started, for 3-4 days. *Hereditary angioedema:* Adult: 1-1.5 gm 2-3 times daily. *General fibrinolysis:* Adult: 1 gm (or 15 mg/kg)every 6-8 hr. *Inhibition of fibrinolysis, hereditary angioedema:* ORAL: Children 1 mth-18 yr: 15-25mg/kg (max 1.5 gm) 2-3 times daily. BY IV INJ: Children 1-18 yr: 10 mg/kg (max 1 g,) 2-3times daily IV injection over at least 10minutes. BY CONTINUOUS IV INF: Adult: 45 mg/kg over 24 hr. Not recommended for children below 1 year of age. *Prevention of excessive bleeding after dental procedures (inhaemophiliac):* BY IV INJ: Pre-operatively, Children 6-18 yrs:10 mg/kg (max 1.5 gm). ORAL: Pre-operatively, Children6-18 yrs: 15-25 mg/kg (max 1.5 gm). Postoperatively, Children 6-18 yr:15-25 mg/kg (max 1.5 gm) 2-3 times daily forup to 8 days.

IV injection or administer as IV continuous infusion. 25-50 .09 over 24hours. Can be mixed with solutions forinfusion such as NS or DOW.

thromboembolism, renal disease, color blindness, haematuria.

Perform regular eye examinations and liver function tests in long-term treatment of hereditary angioedema.

Renal failure, myopathy, intracranial thrombosis, gastrointestinal disorders, nausea, vomiting, diarrhoea, purpura, colour vision disturbances (discontinue) giddiness on rapid IV injection.