📋 Indications & Clinical Dosage
*Haemorrhage, treatment of blood loss in menorrhagia:*
ORAL: Adults: 500 mg 4 times daily during menstruation.
Children: Not recommended.
BY IV OR IM INJ: Adults: Pre-surgically1-2 ampoules IV/IM (250-500mg) 1 hr before surgery. Repeat the dosage if necessary. Postsurgically, 1-2 ampoules (250-500mg) every 4-6 hrs as long as the risk of bleeding persists. Emergency cases; according to the severity: 1-2ampoules IV/IM every 4-6 hrs as long as the bleeding risk persists. Local treatment Soak a swab with the contents of one ampoule and apply to haemorrhagic area or in the tooth socket after dental extraction.
Children: Not recommended.
⛔ Contraindications
Acute porphyria.
⚠️ Precautions & Warnings
Exclude structural or histological causes of menorrhagia, or fibroids causing distortion of the uterine cavity, before initiating treatment.
⚠️ Adverse Reactions / Side Effects
Nausea, vomiting, diarrhoea, fever (discontinue), headache, skin rash.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised
Lactation / Breastfeeding:
Not recommended
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.