📋 Indications & Clinical Dosage
*Passive immunization and Post-exposure prophylaxis against rabies infection:*
BY LOCAL INFILTRATION, OR BY IM INJ: Adult & Children: 20 units/kg, dose administered by infiltration in and around the cleansed wound; if the wound not visible or healed or if infiltration of whole volume not possible, give remainder by IM injection into anterolateral thigh (remote from vaccination site).
⛔ Contraindications
IgA deficiency, interference with live virus vaccines.
⚠️ Precautions & Warnings
History of typical reactions to blood or blood products, risk factors for thrombotic events or acute renal failure. Monitor for adverse reactions and anaphylactoid reactions during infusion.
🔄 Drug Interactions
May interfere with live vaccines to induce an immune response and a suitable interval should separate their administration.
⚠️ Adverse Reactions / Side Effects
Anaphylaxis, facial oedema, injection site pain and swelling arthralgia, buccal ulceration, chest tightness, dizziness, dyspnea, glossitis, tremor
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.