📋 Indications & Clinical Dosage
*Therapeutic termination of pregnancy:*
BY INTRA-AMNIOTICAL: Adult (female): 40 mg by slowly injecting 8 ml of a solution containing 5 mg/ml into the amniotic sac. A further dose of 10 to 40 mg after 24 hr may be given if the membranes are still intact.Should not be given continuously for more than 2 days, for the termination of pregnancy during the sec trimester, see literature.
⛔ Contraindications
Pelvic infection; cervicitis, vaginal infections (extra-amniotic route); history of caesarean section or major uterine surgery.
PRECAUTIONS: Incomplete termination, history of asthma, glaucoma, raised intraocular pressure, high tone myometrial contractions.
⚠️ Adverse Reactions / Side Effects
Pain and discomfort in pelvic area, nausea, vomiting, diarrhoea, blood loss, uterine infections, fever.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.