AROMASIN (EXEMESTANE) Price

Dosage Form	Reg. No	Pack Size	Trade Price (TP)	Maximum Retail Price (MRP)
Tab 25 mg	—	15	Rs.7944.00	Rs.9345.88

📋 Indications & Clinical Dosage

*Adjuvant treatment of oestrogen-receptor-positive early breast cancer in postmenopausal women following 2-3 years of tamoxifen therapy, advanced breast cancerin postmenopausal women in whom anti-oestrogentherapy has failed:* Adult: 25 mg daily after a meal. In early breast cancer, continue treatment until completion of 5 yr combined sequential adjuvant therapy with tamoxifen, or earlier if tumour relapses. In advanced breast cancer continue treatment until subsided. Children: Not recommended.

⛔ Contraindications

Pre-menopausal women.

⚠️ Precautions & Warnings

Assess LH, FSH and oestradiol level before the treatment, hepatic or renal impairment. Monitor bone mineral density during adjuvant therapy, treat for osteoporosis as appropriate.

🔄 Drug Interactions

Drug metabolised by CYP3A4 that have a narrow therapeutic ratio, oestrogen.

⚠️ Adverse Reactions / Side Effects

Abdominal pain, alopecia, anorexia, constipation, depression, dizziness, dyspepsia, fatigue, headache, hot flushes, insomnia, nausea, rash, sweating, vomiting, asthenia, drowsiness, peripheral oedema. Rare: Leucopenia, thrombocytopenia

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:

Contraindicated in pregnancy.

Lactation / Breastfeeding:

Contraindicated. Discontinue breast-feeding.

📚 Official Regulatory & Clinical References

Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.