📋 Indications & Clinical Dosage
*Apnoea in premature newborn babies:*
BY SLOW IV INF: Neonates: loading dose: 20mg/kg INF over 30 minutes. After an interval of 24 hours, maintenance dose of 5 mg/kg may be administered by INF over 10 minutes every 24 hours. Maintenance dose may be given by oral administration.
⚠️ Precautions & Warnings
Cardiovascular disease, impaired renal or hepatic function, GERD, increased heart rate, increase in metabolism, diuresis and electrolytes imbalance.
🔄 Drug Interactions
Theophylline.
⚠️ Adverse Reactions / Side Effects
GI disturbance, irritability, restlessness and jitteriness, tachycardia, hypertension, see literature.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.