📋 Indications & Clinical Dosage
*Bronchial asthma, pulmonary infections with bronchospastic component:*
Adults: 1 dragee in the morning and 1 dragee in the evening before meals. Dosage can vary from 900 to 1800 mg daily according to response.
Children: Not recommended.
⛔ Contraindications
Acute myocardial infarction, hypersensitivity to xanthine derivatives
⚠️ Precautions & Warnings
Heart failure, serious hypertension, hepatic & renal insufficiency, gastric ulcer and hyperthyroidism.
🔄 Drug Interactions
Erythromycin, TAO, lincomycin, clindamycin, al-lopurinol, cimetidine, anti-influenza vaccine, propranolol, phenytoin, other anticonvulsants, cigarettes smoking, other xanthine compounds, ephedrine or other broncho-dilating sympathomimetics.
⚠️ Adverse Reactions / Side Effects
GI distress, headache, gastralgia, nausea, slight tremors, urticaria, itching, rash.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised
Lactation / Breastfeeding:
Caution advised
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.