📋 Indications & Clinical Dosage
*Relief of pain, fever associated with acute & chronic rheumatism, dysmenorrhoea, neuralgia, tonsillitis, influenza, coryza, headaches:*
Adults & Children above 12 yrs: 1-2 tab three to four times a day.
⛔ Contraindications
Previous or active peptic ulceration, haemophilia and other bleeding disorders, severe renal or hepatic impairment.
🔄 Drug Interactions
Oral anticoagulants, heparin, anti-platelet agents, fibrinolytics, NSAIDs, uricosuric agents, methotrexate, SSRIs, venlafaxine, corticosteroids, acetazolamide, drugs which delay gastric emptying (e.g. anticholinergics, narcotics).
⚠️ Adverse Reactions / Side Effects
Cyanosis, skin eruptions, hypoglycaemia, CNS stimulations, bronchospasm, GI upset, allergic reactions, GI and other haemorrhage. Tinnitus, vertigo, confusion, increased bleeding.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised, avoid at full term
Lactation / Breastfeeding:
Caution advised
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.