📋 Indications & Clinical Dosage
*Hyponatraemic and hypokalaemic dehydration due to severe diarrhoea, water and electrolytes insufficiency due to various conditions:*
Adults: 500-1000 ml at the rate of 300-500 mmol/hr (about 75-125 drops per min.
Children: 50-1000 ml per hr (about 12-25 drops per min).
⚠️ Precautions & Warnings
Cardiac failure. Reduced urinary output due to obstructive urinary tract diseases, hypertonic dehydration, renal failure due to renal diseases. Sodium Chloride content of this solution is 9.0 gm/litre whereas, the daily requirement of NaCI for an adult is 3-6 gm. Therefore, care should be taken in those cases where salt intake is restricted as in oedema, hypertension etc.
⚠️ Adverse Reactions / Side Effects
Cerebral, pulmonary and peripheral oedema, congestive heart failure, acidosis and electrolyte imbalance may occur with a large volume and/or rapid infusion.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.