📋 Indications & Clinical Dosage
*Treatment of hepatic encephalopathy, in patients with chronic liver disease:*
BY IV INF: Adults: 500-1000 ml per dose. The usual peripheral INF rate is 500 ml over 180-300 min in adults. For total parenteral nutrition, 500-1000 ml in Aminoleban should be combined with dextrose or other solutions and administered over 24 hr via a central vein. The dosage may be adjusted according to the patients body weight.
⛔ Contraindications
Patient with severe renal disorder and those with abnormal amino acids metabolism.
⚠️ Precautions & Warnings
Patients with severe acidosis and those with congestive cardiac failure.
⚠️ Adverse Reactions / Side Effects
Hypoglycaemia may occur and hyperammonaemia has been reported. Hypersensitivity reactions such as skin rash may occur rarely. Nausea, vomiting, chest discomfort and palpitations may occur infrequently. Large doses and rapid administration may lead to acidosis. Chills, fever and headache may infrequently occur.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.