📋 Indications & Clinical Dosage
*To control outbreaks of hepatitis A:*
BY DEEP IM INJ: Adult: 500-750 mg
*Rubella in pregnancy, prevention of clinical attack:*
Females of childbearing potential: 750 mg.
*Antibody deficiency syndromes:*
BY SC INF: Adult: (consult product literature)
⛔ Contraindications
Patients with selective IgA deficiency who have known antibody against IgA
⚠️ Precautions & Warnings
Agammaglobulinaemia with or without IgA deficiency, hypogammaglobulinaemia with or without IgA deficiency, interference with live virus vaccines; normal immunoglobulin may interfere with the immune response to live virus vaccines which should therefore only be given at least 3 weeks before or 3 months after an injection of normal immunoglobulin (except yellow fever vaccine since normal immunoglobulin does not contain antibody to this virus)
🔄 Drug Interactions
interference with live virus vaccines
⚠️ Adverse Reactions / Side Effects
Arthralgia, chills, diarrhoea, dizziness, fever, headache, low back pain, muscle spasms, myalgia, nausea. Rare: Acute renal failure, anaphylaxis, aseptic meningitis, cutaneous skin reactions, hypotension
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.