📋 Indications & Clinical Dosage
*Primary immunization against measles and rubella:*
BY IM INJ, OR BY DEEP SC INJ: First dose: Children 12-13 months: 0.5 ml for first dose. For Second dose: Children 40 months-5 years: 0.5 ml for 1 dose
Consult product literature.
⛔ Contraindications
Pregnancy, Impaired immunity.
⚠️ Precautions & Warnings
Acute, severe febrile illness, history of convulsions, anaphylactic egg allergy. Evaluate serological status when second dose is due in children who developed thrombocytopenic purpura within 6 weeks of first dose, lactation. Antibody response to measles component maybe reduced after immunoglobulin administration or bloodtransfusion; leave an interval of at least 3 months beforeMMR immunization
🔄 Drug Interactions
Do not give within 3 weeks of other live vaccines, or within 3 months of blood transfusion or immunoglobulins. Tuberculin test should be done before or simultaneously with vaccination.
⚠️ Adverse Reactions / Side Effects
Parotid swelling (usually in the third week), sleep disturbances, unusual crying in infants. Rare: Arthropathy (2 to 3 weeks after immunisation), idiopathic thrombocytopenic purpura,optic neuritis, peripheral neuritis,
malaise, fever, or a rash can occur after the first dose of MMR vaccine; most commonly about a week aftervaccination and lasting about 2 to 3 days, febrile seizures-occur rarely 6 to 11 days after MMRvaccination
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.