📋 Indications & Clinical Dosage
*Type 2 diabetes mellitus as monotherapy, or in combination with metformin, and/or a sulfonylurea (when dual therapy with these drugs fails to achieve adequate glycaemic control). Type 2 diabetes mellitus in combination with insulin (with or without metformin) when insulin has not provided adequate glycaemic control:*
Adult: 5 mg once daily. Reduced dose in case of concomitant sulfonylurea or insulin.
🔄 Drug Interactions
Potent CYP3A4 and P-gp inducer
⚠️ Adverse Reactions / Side Effects
Cough, nasopharyngitis, Pancreatitis Discontinue if symptoms of acute pancreatitis (persistent, severe abdominal pain)
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated in pregnancy
Lactation / Breastfeeding:
Contraindicated or not recommended
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.