📋 Indications & Clinical Dosage
*Dermatophyte infections of the skin, scalp, hair and nails where topical therapy has failed or is inappropriate:*
Adult: 500 mg once daily or in divided doses, increased if necessary to 1 g daily, for severe infections; reduce dose according to response.
Children less than 50 kg body weight: 15-20 mg/kg once daily or in divided doses.
*Tineacapitis caused by Trichophytontonsurans:*
Adult: 1 g once daily, alternatively 1 g daily in divided doses.
Children less than 50 kg body weight: 15-20 mg/kg once daily or in divided doses.
🔄 Drug Interactions
Warfarin type anticoagulant, barbiturates, coumarins, oral contraceptives.
⚠️ Adverse Reactions / Side Effects
Abdominal pain, headache, nausea, vomiting, diarrhoea; dyspepsia, hepatotoxicity, glossitis, taste disturbances, sleep disturbances, dizziness, fatigue, confusion, agitation, depression, impaired coordination and hearing, peripheral neuropathy, menstrual disturbances, renal failure, leucopenia, systemic lupus erythematosus, rash (including rarely erythema multiforme, toxic epidermal necrolysis), and photosensitivity