GRAVIBINAN

*Prophylaxis of abortion:* BY IM INJ: Adult (female): Three days after the rise in basal body temperature on about the 18th day of the cycle, 1ml by IM. Where failure of the menstrual bleeding and continued elevation of the basal body temperature Indicate an early pregnancy, an IM injection of 1 ml is given immediately. The hormone dose is doubled one week later, i.e. from the beginning of the sixth week of pregnancy. 2 ml is administered every week during the first month of pregnancy, or longer if necessary. When a patient with a predisposition to habitual abortion does not come for treatment until after the start of the fresh pregnancy, 2 ml is injected immediately, followed by 2 ml every week during the first month of pregnancy, or longer if required. *Threatened abortion:* To institute treatment, 2 ml twice a week until the bleeding stops. Bed rest is urgently advised during this time. When the bleeding ceases, 2 ml weekly for some weeks until the patient is free from complaints and bleeding despite mobilisation.

A history of herpes of pregnancy, throm boembolic processes.

Hypertension, myocardial or renal disease, asthma, varicose veins, epilepsy, chloasma, uterine fibromyomata. Examine BR pelvic organs & breasts before & regularly during treatment.

Diuretics, antihypertensives, liver enzyme inducing drugs.

Nausea, vomiting, weight gain, breast ten-derness & enlargement, withdrawal bleeding, sodium retention with oedema, liver function disorders, jaundice, rashes, chloasma, headache.