🩺 DRUGS FOR BENIGN PROSTATIC HYPERTROPHY 🏷️ Selective alpha-1 blocker
👨‍⚕️ Clinically Reviewed by: PakistaniBano Medical Editorial Board (Pharm.D Panel)
📅 Reviewed: November 2026 • 🔍 Authority: DRAP / WHO ATC
📦 Formulations, Pack Sizes & Retail Prices Currency: Rs.
Dosage Form Reg. No Pack Size Trade Price (TP) Maximum Retail Price (MRP)
Tab 10 mg 098325 30 1233.88 — Rs.1451.62

📋 Indications & Clinical Dosage

*Benign prostatic hyperplasia:* Adult: 10 mg once daily, Elderly: 5 mg morning and evening. Children: Not recommended. *Acute urinary retention associated with benign prostatic hyperplasia:* Elderly: 10 mg once daily for 2-3 days during catheterisation and for one day after removal; max. 4 days.

⛔ Contraindications

History of orthostatic hypotension, avoid if history micturition syncope

⚠️ Precautions & Warnings

First dose may cause collapse due to hypotensive effect (therefore should be taken on retiring to bed). Patients should be warned to lie down if symptoms such as dizziness, fatigue or sweating develop, and to remain lying down until they abate completely. Use with caution in hypertension; monitor BP regularly, particularly at start of treatment. Coronary insufficiency; discontinue if angina deteriorates. Withdraw 24 hours before anaesthesia, acute heart failure, history of QT-interval prolongation, patients undergoing cataract surgery (risk of intra-operative floppy iris syndrome), renal and hepatic impairment (reduce dose)

🔄 Drug Interactions

Other alpha-blockers, antihypertensives, calcium antagonists

⚠️ Adverse Reactions / Side Effects

Angioedema, asthenia, blurred vision, cholestasis, depression, dizziness, drowsiness, dry mouth, erectile disorders (including priapism),GI disturbances, headache, hypersensitivity, hypotension, intra-operative floppy iris syndrome, liver damage, oedema, palpitations, pruritus, rash, rhinitis, syncope, tachycardia, hot flushes, chest pain

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:
No evidence of risk in humans
Lactation / Breastfeeding:
Contraindicated, avoid

📚 Official Regulatory & Clinical References

  • Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
  • World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
  • Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

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