FLUDARA (FLUDARABINE PHOSPHATE) Price

Dosage Form	Reg. No	Pack Size	Trade Price (TP)	Maximum Retail Price (MRP)
IV Inj50 mg	—	5 Vial	Rs.56366.49	Rs.66313.52

📋 Indications & Clinical Dosage

*Initial treatment of advanced B-cell chronic lymphocytic leukaemia (CLL), First-line treatment in patients with sufficient bone-marrow reserves:* BY IV INJ: Adult: 50 mg daily for 5 days every 28 days, usually givenfor 6 cycles. See product literature. Children: Not recommended.

💊 Mode of Administration

Administer over 15-30 min or continuous infusion. Reconstitute vials with SWFI, NS, or D5W to a concentration of 10-25 mg/ml. Standard IV dilution: 50-100 ml D5W or NS.

⛔ Contraindications

Haemolytic anaemia

⚠️ Precautions & Warnings

Use with caution in renal insufficiency, fever, documented infection or pre-existing hematological disorder or CNS disorders or peripheral neuropathy. Increased susceptibility to skin cancer, worsening of existing skin cancer

🔄 Drug Interactions

Pentostatin, ethanol.

⚠️ Adverse Reactions / Side Effects

Acutemyeloid, leukaemia,anorexia, chills, cough, diarrhoea, fever, immunosuppression, malaise, myelodysplastic syndrome, myelosupression, oedema, peripheral neuropathy, pneumonia, rash, visualdisturbances, weakness, autoimmune disorder, confusion, fibrosis,haemorrhage, immune-mediated haemolytic anaemia,neutropenia, pneumonitis, pulmonary toxicity, thrombocytopenia, alopecia, bone-marrow suppression, extravasation, haemorrhagic cystitis, hyperuricaemia, nausea, oral mucositis, thromboembolism, tumourlysis syndrome, vomiting. Rare: Agitation, arrhythmia, blindness, coma, heart failure, optic neuropathy, seizures, skin cancer, Stevens- Johnson syndrome, toxic epidermal necrolysis

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:

Positive evidence of risk: Avoid

Lactation / Breastfeeding:

Contraindicated. Discontinue breast-feeding.

🧪 Compatibility & Storage Stability

Compatibility: Stable in D5W, NS, SWFI

Stability & Storage: Store intact vials under refrigeration at 2C-8C. Reconstituted vials are stable for 16 days at room temperature of 15C-30C.

📚 Official Regulatory & Clinical References

Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.