📋 Indications & Clinical Dosage
*HRT for oestrogen deficiency in woman after menopause, Menopausal symptoms:*
Adult (female):1 orange tab daily for 14 days, starting within 5 days of onset of menstruation (or any time if cycles have ceased or are infrequent) then 1 yellow tablet daily for 14 days; subsequent courses repeated without interval; where therapy required for menopausal symptoms alone.
*Osteoporosis prophylaxis:*
Adult: 1 tab daily.
⛔ Contraindications
Known or suspected breast cancer or oestrogen-dependent malignant tumour, active thrombophlebitis, active or history or thromboembolic disease or VTE, thrombophilic disorders, acute liver disease, severe renal impairment, untreated endometrial hyperplasia, undiagnosed vaginal bleeding, porphyria, pregnancy lactation
⚠️ Precautions & Warnings
Hypertension, myocardial or renal disease, asthma, varicose veins, epilepsy, chloasma, uterine fibromyomata. Examine BP, pelvic organs & breasts before & regularly during treatment.
⚠️ Adverse Reactions / Side Effects
Breast tenderness & enlargement, withdrawal bleeding, endometrial carcinoma in post-meno-pausal women, nausea, vomiting, weight gain, sodium retention with oedema, liver function disorders, jaundice, rashes, chloasma, headache.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.