DIVIR (DIDANOSINE) Price

Dosage Form	Reg. No	Pack Size	Trade Price (TP)	Maximum Retail Price (MRP)
Tab 200 mg	045670	60. 5950.00	—	Rs.7000.00

📋 Indications & Clinical Dosage

*HIV infection in combination with other antiretroviral drugs:* Adult: body-weight less than 60 kg: 250 mg daily in1-2 divided doses; body-weight 60 kg and above: 400 mg daily in1-2 divided doses Children below 3 months:200 mg/mu (180 mg/mu daily in combination with zidovudine) in 1-2 divided doses.

⚠️ Precautions & Warnings

Combination treatment of didanosine & stavudine during pregnancy, patient with risk factors for liver disease, pancreatitis, risk factors for pancreatitis e.g. patients with advanced HIV infection, patients with combination antiretroviral therapy, history of pancreatitis, elderly, paediatric patients, renal & hepatic impairment, peripheral neuropathy. Periodic retinal exam is recommended, hyperuricaemia, immune reconstitution syndrome & patients with restricted diets.

🔄 Drug Interactions

Co-administration with drugs known to cause peripheral neuropathy or pancreatitis may increase the risk of these toxicities. Allopurinol; methadone; tenofovir; delavirdine & indinavir; ketoconazole & itraconazole' ganciclovir; tetracyclines; quinolones, ribavirin

⚠️ Adverse Reactions / Side Effects

Acute renal failure, alopecia, anaphylactic reactions, diabetes mellitus, dry eyes, dry mouth, hyperuricaemia, (suspend if raised significantly), hypoglycaemia, lactic acidosis, lipodystrophy, liver failure, non-cirrhotic portal hypertension, optic nerve changes, pancreatitis, parotid gland enlargement, peripheral neuropathy (switch toanother antiretroviral if peripheral neuropathy develops), retinal changes, rhabdomyolysis, sialadenitis

📚 Official Regulatory & Clinical References

Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

DRAP Registration Number: 045670