CYTOBLASTIN (VINBLASTINE SULFATE) Price

Dosage Form	Reg. No	Pack Size	Trade Price (TP)	Maximum Retail Price (MRP)
Inj 10 mg	045653	1 Vial	Rs.552.50	Rs.650.00

📋 Indications & Clinical Dosage

*Hodgkins disease, Lymphocytic lymphoma, Histiocytic lymphoma, Advanced mycosis fungoides, Advanced testicular cancer, Kaposis sarcoma, LettererSiwe disease, Resistant choriocarcinoma, Unresponsive breast cancer:* BY IV INJ OR INF: Adults: At weekly intervals:1st dose=3.7 mg/m2, 2nd dose=5.5 mg/m2, 3rd dose=7.4 mg/m2, 4th dose=9.25 mg/m2, 5th dose= 11.1 mg/m2, increase to a max 18.5 mg/m2. Children: At weekly intervals: 1st dose=2.5 mg/ rn2, 2nd dose=3.75 mg/m2, 3rd dose=5 mg/m2, 4th dose=6.25 mg/m2, 5th dose= 7.5 mg/m2, increase to a max 12.5 mg/m2.

💊 Mode of Administration

For IV administration only, usually as a slow (2-3 min) push, or a bolus (5-15 min) infusion. It is occasionally given as a 24-hour continuous infusion. Reconstitute to a cone of 1 mg/ml with bacteriostatic water, bacteriostatic NS, SWFI, NS, or D5W; for infusion, may be diluted with 50-1000 ml NS or D5W.

⛔ Contraindications

Bone marrow suppression.

⚠️ Precautions & Warnings

Intrathecal administration can cause severe neurotoxicity which may result in death.

🔄 Drug Interactions

Mitomycin C, CYP3A4 enzyme inhibitors.

⚠️ Adverse Reactions / Side Effects

Alopecia, autonomic neuropathy, hyperuricaemia, loss of deep tendon reflexes, motor weakness, myelosuppression(dose-limiting), nausea neurotoxicity, oral mucositis, ototoxicity, peripheral neuropathy, peripheral paraesthesia, severe bronchospasm following administration, severe local irritation, thromboembolism, tumourlysis syndrome, vomiting

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:

Positive evidence of risk: Avoid

Lactation / Breastfeeding:

Contraindicated. Discontinue breast-feeding

🧪 Compatibility & Storage Stability

Compatibility: Stable in D5W, LR, NS, bacteriostatic water.

📚 Official Regulatory & Clinical References

Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

DRAP Registration Number: 045653