📋 Indications & Clinical Dosage
*Acute back pain, post- operative pain, pain in acute trauma and fractures, renal colic:*
BY IM INJ: Adults: 75 mg once or twice daily by deep intragluteal inj for max 2 days. Continue if necessary with tab. Children: Not recommended.
⛔ Contraindications
Active peptic ulcer, aspirin/anti-inflammatory induced allergy, proctitis.
⚠️ Precautions & Warnings
Monitor patients on long-term treatment, history of GIlesions, renal, hepatic or cardiac insufficiency, hepatic porphyria, haematological abnormalities, elderly
🔄 Drug Interactions
Salicylates, methotrexate, lithium, digoxin, diuretics, cyclosporin, anticoagulants, oral hypoglycaemics, quinolones, NSAIDs, steroids.
⚠️ Adverse Reactions / Side Effects
GI ulceration, transient epigastric pain, GI disturbances, headache, oedema, skin reactions, pain at injection site. Rarely blood dyshaematopoiesis, peptic ulcer, abnormalities of liver and kidney function.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated in pregnancy
Lactation / Breastfeeding:
Contraindicated or not recommended
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.