📋 Indications & Clinical Dosage
*Type 2 Diabetes mellitus, maturity-onset diabetes mellitus:*
Adult: Initially 5 mg daily, adjusted according to response, dose to be taken with or immediately after breakfast; max. 15 mg per day.
Children: Not recommended.
⛔ Contraindications
Acute porphyria, renal and hepatic disease, diabetic coma insulin-dependent diabetes.
⚠️ Precautions & Warnings
Cross-sensitivity to sulfonamides and sulfonamide derivative. Not licensed for use in breast feeding women with pre-existing diabetes and gestational diabetes
🔄 Drug Interactions
Potentiation of hypoglycaemic effects with alcohol, beta-blockers, bezafibrate, biguanides, chloramphenicol, clofibrate, coumarin derivatives, MAOIs, salicylates, tetracyclines, attenuation and aggravation of metabolic states by laxatives, corticosteroids, nicotinic acid, oestrogens, phenothiazine derivatives, saluretics, sympathomimetics, thyroid hormones
⚠️ Adverse Reactions / Side Effects
Thrombocytopenia, aplastic anemia, hemolytic anemia, cholestatic jaundice, fictitious hypoglycaemia, agranulocytosis, hepatitis, nausea and sensation of fullness, transient visual disturbance, blood dyscrasias.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Not recommended
Lactation / Breastfeeding:
Contraindicated or not recommended.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.