📋 Indications & Clinical Dosage
*Type 2 Diabetes mellitus, maturity-onset diabetes mellitus:*
Adults: Initial: 250 mg once daily with breakfast, after 5-7 days, adjust by 50-125 mg daily every 3-5 days, may be increased to 100-500 mg daily, max: 750 mg daily.
Children: Not recommended.
⛔ Contraindications
Ketosis, congestive heart failure, gestational diabetes, elderly, children, pregnancy, renal and hepatic impairment.
⚠️ Precautions & Warnings
High blood pressure, risk of photosensitization.
⚠️ Adverse Reactions / Side Effects
Thrombocytopenia, a plastic anemia, hemolytic anemia, cholestatic jaundice, fictitious hypoglycaemia, agranulocytosis, hepatitis, exfoliative dermatitis, eosinophilic pulmonary infilterates.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Not recommended.
Lactation / Breastfeeding:
Not recommended.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.