DAUNOTEC (DAUNORUBICIN) Price

Dosage Form	Reg. No	Pack Size	Trade Price (TP)	Maximum Retail Price (MRP)
Inj 20 mg	045601	1 Vial	Rs.485.00	Rs.570.00

📋 Indications & Clinical Dosage

*Acute myelogenous leukaemia, Acute lymphocytic Leukaemia, Advanced AIDS-related Kaposis sarcoma:* BY IV INF: Adults: 0.8 mg/kg continue with a maintenance dose of 0.8-1 mg/kg; max 25 mg/kg. (consult product literature). Children: Initial dose of 1 mg/kg of daunomycin daily for 4-5 days, max 25 mg/kg. (consult product literature).

💊 Mode of Administration

Never administer IM or SC. Administer IVP over 1-5 min into the tubing of a rapidly infusing IV solution of D5W or NS; Daunorubicin has also been diluted in 100 ml of D5W or NS and infused over 15-30 min. Dilute vials with 4 ml SWFI for a final concentration of 5 mg/ml.

⛔ Contraindications

Myocardial insufficiency, previous treatment with maximum cumulative doses of daunorubicin or other anthracycline, recent myocardial infarction, severe arrhythmia, severe renal or hepatic impairment.

⚠️ Precautions & Warnings

Renal and hepatic impairment, Caution is necessary with concomitant use of cardiotoxic drugs, or drugs that reduce cardiac contractility. Cardiac function should be monitored closely.

🔄 Drug Interactions

BCG; clozapine; natalizumab; pimecrolimus; tacrolimus (topical); live vaccines (avoid), leflunomide, roflumilast, trastuzumab.

⚠️ Adverse Reactions / Side Effects

A lopecia,bone-marrow suppression, extravasation, hyperuricaemia, nausea, oral mucositis, thromboembolism, tumourlysis syndrome, vomiting, cardiotoxicity

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:

Positive evidence of risk: Avoid

Lactation / Breastfeeding:

Contraindicated. Discontinue breast feeding

🧪 Compatibility & Storage Stability

Compatibility: Stable in D5W, LR, NS, SWFI.

📚 Official Regulatory & Clinical References

Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

DRAP Registration Number: 045601