📋 Indications & Clinical Dosage
*Acute myelogenous leukaemia, Acute lymphocytic Leukaemia, Advanced AIDS-related Kaposis sarcoma:*
BY IV INF: Adults: 0.8 mg/kg continue with a maintenance dose of 0.8-1 mg/kg; max 25 mg/kg. (consult product literature).
Children: Initial dose of 1 mg/kg of daunomycin daily for 4-5 days, max 25 mg/kg. (consult product literature).
💊 Mode of Administration
Never administer IM or SC. Administer IVP over 1-5 min into the tubing of a rapidly infusing IV solution of D5W or NS; Daunorubicin has also been diluted in 100 ml of D5W or NS and infused over 15-30 min. Dilute vials with 4 ml SWFI for a final concentration of 5 mg/ml.
⛔ Contraindications
Myocardial insufficiency, previous treatment with maximum cumulative doses of daunorubicin or other anthracycline, recent myocardial infarction, severe arrhythmia, severe renal or hepatic impairment.
⚠️ Precautions & Warnings
Renal and hepatic impairment, Caution is necessary with concomitant use of cardiotoxic drugs, or drugs that reduce cardiac contractility. Cardiac function should be monitored closely.
🔄 Drug Interactions
BCG; clozapine; natalizumab;
pimecrolimus; tacrolimus (topical); live vaccines (avoid), leflunomide, roflumilast, trastuzumab.
⚠️ Adverse Reactions / Side Effects
A lopecia,bone-marrow suppression, extravasation, hyperuricaemia, nausea, oral mucositis, thromboembolism, tumourlysis syndrome, vomiting, cardiotoxicity
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Positive evidence of risk: Avoid
Lactation / Breastfeeding:
Contraindicated. Discontinue breast feeding
🧪 Compatibility & Storage Stability
Compatibility: Stable in D5W, LR, NS, SWFI.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.