๐Ÿฉบ ANTIMYCOTICS SYSTEMIC USE ๐Ÿท๏ธ Antifungal, Echinocandin Antifungal
๐Ÿ‘จโ€โš•๏ธ Clinically Reviewed by: PakistaniBano Medical Editorial Board (Pharm.D Panel)
๐Ÿ“… Reviewed: November 2026 โ€ข ๐Ÿ” Authority: DRAP / WHO ATC
๐Ÿ“ฆ Formulations, Pack Sizes & Retail Prices Currency: Rs.
Dosage Form Reg. No Pack Size Trade Price (TP) Maximum Retail Price (MRP)
Inf 50 mg 106843 1 Rs.25505.00 Rs.30006.00
Inf 70 mg 106844 1 Rs.25505.00 Rs.30006.00

๐Ÿ“‹ Indications & Clinical Dosage

*Invasive aspergillosis, Invasive candidiasis, Empirical treatment of systemic fungal infections in patients with Neutropenia:* BY IV INF: Adult (body-weight up to 81 kg): 70 mg once daily for 1 day, then 50 mg once daily. Adult (body-weight 81 kg and above): 70 mg once daily.

๐Ÿ’Š Mode of Administration

For IV infusion: Give intermittently in Sodium chloride 0.9%. Allow vial to reach room temperature; initially reconstitute each vial with 10.5mL water for injections, mixing gently to dissolve then dilute requisite dose in 250 ml infusion fluid (35- or 50-mg doses may be diluted in 100 ml infusion fluid if necessary); give over 60 minutes; incompatible with glucose solutions.)

โš ๏ธ Precautions & Warnings

Severe hepatic impairment; dose adjustments, use adequate contraception during and for at least 6 months after last dose.

โš ๏ธ Adverse Reactions / Side Effects

Arthralgia, diarrhoea, dyspnoea, electrolyte imbalance, fever, headache, hyperhidrosis, nausea, skin reactions, vomiting, anaemia, anxiety, appetite decreased, arrhythmias, ascites, chest discomfort, coagulation disorder, congestive heart failure, constipation, cough, disorientation, dizziness, drowsiness, dry mouth, dysphagia, excessive tearing, eyelid oedema, fatigue, flatulence, fluid overload, flushing, GI discomfort, haematuria, hepatic disorders, hyperbilirubinaemia, hyperglycaemia, hypertension, hypotension, hypoxia, induration, insomnia, laryngeal, pain, leucopenia, malaise, metabolic acidosis, muscle weakness, myalgia, nasal congestion, oedema, pain, palpitations, renal impairment, respiratory disorders, sensation abnormal, taste altered, thrombocytopenia, thrombophlebitis, tremor, vision blurred, severe cutaneous adverse reactions (SCARs)

๐Ÿคฐ Pregnancy & Lactation Safety

Pregnancy Risk:
Avoid unless essential
Lactation / Breastfeeding:
Avoid

๐Ÿงช Compatibility & Storage Stability

Compatibility: 0.9% NaCl

Stability & Storage: Refrigerate at 2-8 C (36-46 F) or at temperatures up to 30 C (86 F) upon removal from refrigerator, vials cannot be returned to refrigerated storage.

๐Ÿ“š Official Regulatory & Clinical References

  • Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
  • World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
  • Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

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