🩺 CALCIUM CHANNEL BLOCKERS 🏷️ Calcium antagonist/Diuretic
👨‍⚕️ Clinically Reviewed by: PakistaniBano Medical Editorial Board (Pharm.D Panel)
📅 Reviewed: November 2026 • 🔍 Authority: DRAP / WHO ATC
📦 Formulations, Pack Sizes & Retail Prices Currency: Rs.
Dosage Form Reg. No Pack Size Trade Price (TP) Maximum Retail Price (MRP)
Tab 5/12.5 mg 036833 2x10 Rs.122.7 Rs.144.45

📋 Indications & Clinical Dosage

*Hypertension, Myocardial ischaemia:* Adults: Initial dose of 1 tab once daily, may be increased to a max daily dose of 2 tab. Children: Not recommended.

⛔ Contraindications

Cardiogenic shock, aortic stenosis, unstable angina, hypersensitivity to dihydropyridines,

⚠️ Precautions & Warnings

Within one month of MI, impaired hepatic function, hypertensive crisis.

🔄 Drug Interactions

Azole antifungals, erythromycin, cyclosporin, sildenafil, rifampicin, CYP3A4 inhibitors.

⚠️ Adverse Reactions / Side Effects

Headache, oedema, fatigue, nausea, flushing and dizziness, rash, gingival hyperplasia. Rare: Alopecia, pruritus, angioedema, palpitations, dyspnoea, abdominal pain, back pain, dyspepsia, muscle cramps, asthenia, somnolence, altered bowel habit, myalgia, arthralgia, peripheral neuropathy, pancreatitis, mood changes, dry mouth, increased micturition, hyperglycaemia, impotence, sweating, syncope, thrombocytopenia, vasculitis, visual disturbances.

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:
Contraindicated in pregnancy.
Lactation / Breastfeeding:
Not recommended.

📚 Official Regulatory & Clinical References

  • Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
  • World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
  • Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

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