BUSCOPAN

*Symptomatic relief of gastro-intestinal or genitourinary disorders characterized by smooth muscle spasm:* Adults Children above 12 yrs: 20 mg 4 times a day Children 6-11 yrs: 10 mg 3 times a day *Irritable bowel syndrome:* Adult: 10 mg 3 times a day; increased if necessary up to 20 mg 4 times a day *Acute spasm, spasm in diagnostic procedures:* BY IM INJ, OR BY SLOW IV INJ: Adult: 20 mg, then after 30 minutes 20 mg again if required, dose may be repeated more frequently in endoscopy; max. 100 mg per day *Excessive respiratory secretions in palliative care:* ORAL: Children 1 month-1 yr: 300-500 mcg/kg 3-4 times a day (max. per dose 5 mg); 2-4 yrs: 5 mg 3-4 times a day; 5-11 yrs: 10 mg 3-4 times a day; 12-17 yrs: 10-20 mg 3-4 times a day BY IM INJ, OR BY IV INJ: Children 1 month-4 yrs: 300-500 mcg/kg 3-4 times a day (max. per dose 5 mg) 5-11 yrs: 5-10 mg 3-4 times a day 12-17 yrs: 10-20 mg 3-4 times a day BY SC INJ: Adult: 20 mg every 4 hours if required, adjusted according to response to up to 20 mg every 1hour. BY SC INF: Adult: 20-120 mg/24 hours *Bowel colic (in palliative care):* ORAL: Children 1 month-1 yr: 300-500 mcg/kg 3-4 times a day (max. per dose 5 mg) 2-4 yrs: 5 mg 3-4 times a day 5-11 yrs: 10 mg 3-4 times a day 12-17 yrs: 10-20 mg 3-4 times a day BY IM INJ, OR BY IV INJ: Children 1 month-4 yrs: 300-500 mcg/kg 3-4 times a day (max. per dose 5 mg) 5-11 yrs: 5-10 mg 3-4 times a day 12-17 yrs: 10-20 mg 3-4 times a day BY SC INJ: Adult: 20 mg every 4 hours if required, adjusted according to response to up to 20 mg every 1hour. BY SC INF: Adult: 60-300 mg/24 hours *Transdermal Patch: For Motion sickness:* Adults: 1 patch on hairless area of skin behind ear 5-6 hr before journey. If necessary, replace with new patch behind other ear after 72 hr. Children above 10 yrs: Same as adults. Below 10 yr: Not recommended.

Myasthenia gravis (but may be used to decrease muscarinic side-effects of anticholinesterases), paralytic ileus, pyloric stenosis, toxic megacolon, and prostatic enlargement.

Downs syndrome, in children and in the elderly, gastro-esophageal reflux disease, diarrhoea, ulcerative colitis, autonomic, neuropathy, acute myocardial infarction, hypertension, conditions characterized by tachycardia (including hyperthyroidism, cardiac insufficiency, cardiac surgery), pyrexia, and in individuals susceptible to angle-closure glaucoma.

Amantadine, atenolol, digoxin, phenothiazines, tricyclic antidepressants.

Transient bradycardia (followed by tachycardia, palpitation and arrhythmias), reduced bronchial secretions, urinary urgency and retention, dilatation of the pupils with loss of accommodation, photo-phobia, dry mouth, flushing and dryness of the skin. Side-effects that occur occasionally include confusion (particularly in the elderly), constipation, nausea, vomiting, and giddiness. Very rare! , angle-closure glaucoma may occur.