📋 Indications & Clinical Dosage
*Monotherapy or adjunct to beta-blockers, in open-angle glaucoma or ocular hypertension:*
Adults: 1 drop twice daily.
⚠️ Precautions & Warnings
Cerebral or coronary insufficiency, renal or hepatic impairment. Raynauds syndrome, orthostatic hypotension, severe cardiovascular disease; monitor cardiac function, hyperthyroidism, unstable angina, severe peripheral or central circulatory disorders, hypotension, diabetes, metabolic acidosis, pheochromocytoma, depression, thromboangiitis obliterans, soft contact lenses; wait minimum 15 min before inserting.
🔄 Drug Interactions
MAOls, antidepressants affecting noradrenergic transmission, CNS depressants, antihypertensives, cardiac glycosides, sympathomimetic agonists.
⚠️ Adverse Reactions / Side Effects
Headache, fatigue drowsiness, ocular hyperaemia, conjunctival follicles, stinging, pruritus, oedema, allergy, dry mouth
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
: Caution advised
Lactation / Breastfeeding:
Not recommended.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.