📋 Indications & Clinical Dosage
*Monotherapy or adjunct to beta-blockers, in open angle glaucoma & ocular hypertension:*
Adults: 1 drop in the affected eye two or three times daily.
⛔ Contraindications
Hepatic or severe renal impairment, hyperchloraemic acidosis, history of hypersensitivity to sul-phonamide.
⚠️ Precautions & Warnings
Cerebral or coronary insufficiency, Pseudo-exfoliative glaucoma, pigmentary glaucoma, narrow-angle glaucoma, diabetes, contact lense wearers, corneal disorder, dry eye condition; monitor closely.
🔄 Drug Interactions
Carbonic anhydrase inhibitors, CYP3A4 inhibitors.
⚠️ Adverse Reactions / Side Effects
Headache, burning sensation, stinging, depression, conjunctival hyperaemia, conjunctival folliculosis, transient disturbed vision, ocular discomfort, hyperaemia, taste perversion.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised
Lactation / Breastfeeding:
Not recommended.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.