📋 Indications & Clinical Dosage
*Constipation:*
ORAL: Adult: 10-20 mg once daily at night.
Children 4-17 years: 5-20 mg once daily, adjusted according to response, at night.
BY RECTUM: Adult: 10 mg once daily, in the morning.
Children 2-17 years: 5-10 mg once daily, adjusted according to response.
*Bowel clearance before radiological procedures and
Surgery:*
ORAL: Adult: 10 mg twice daily, in themorning and evening on the day before procedure and (by rectum) 10 mg, 1-2 hours before procedure the following day.
Tablets act in 10-12 hours; Rectal Suppositories act in20-60 min.
⛔ Contraindications
Acute abdominal conditions, acute inflammatory bowel disease, acute surgical abdominal conditions intestinal obstruction, severe dehydration, undiagnosed abdominal conditions.
⚠️ Precautions & Warnings
Risk ofelectrolyte imbalance with prolonged use.
⚠️ Adverse Reactions / Side Effects
Abdominal cramp, colitis, nausea, vomiting, diarrhea and hypokalaemia (excessive use), local irritation with rectal use.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised.
Lactation / Breastfeeding:
Caution advised or effect undetermined.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.