📋 Indications & Clinical Dosage
*Chronic constipation:*
ORAL: Children 12 above yrs & adult: Up to 500 mg daily in divided doses, adjusted according to response.
BY RECTUM: Adult: 120 mg for 1 dose
*Adjunct in abdominal radiological procedures:*
ORAL: Adult & Children 12 above yrs: 400 mg, to be administered with barium meal.
BY RECTUM: Adult &Children 12 above yrs: 120 mg for 1 dose.
Oral tablets act within 1-2 days; rectal enema act within 20 minutes.
Children Below 12 yr: Not recommended.
⛔ Contraindications
Inflammatory bowel disease, abdominal pain, GI obstruction, nausea, vomiting.
⚠️ Precautions & Warnings
Risk of electrolyte imbalance with prolonged use.
⚠️ Adverse Reactions / Side Effects
Abdominal cramp, diarrhoea (excessive use), hypokalaemia, nausea, skin rash.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised.
Lactation / Breastfeeding:
Caution advised
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.