👨‍⚕️ Clinically Reviewed by: PakistaniBano Medical Editorial Board (Pharm.D Panel)
📅 Reviewed: November 2026 • 🔍 Authority: DRAP / WHO ATC
📦 Formulations, Pack Sizes & Retail Prices Currency: Rs.
Dosage Form Reg. No Pack Size Trade Price (TP) Maximum Retail Price (MRP)
Tab 20 mg 036040 2x10 Rs.141.95 Rs.167.00
Tab 40 mg 036041 10 Rs.119.85 Rs.141.00

📋 Indications & Clinical Dosage

*Treatment of benign gastric and duodenal ulceration:* Adult: 40 mg once daily for 4-8 weeks, dose to be taken at night. *Prophylaxis of duodenal ulcer relapse:* Adult: 20 mg once daily, dose to be taken at night. *Zollinger-ellison syndrome:* Initially 20 mg every 6 hr, adjust as necessary; max 800 mg daily. *Reflux oesophagitis:* Adult: 20-40 mg twice daily for 6-12 weeks; maintenance 20 mg twice daily

⛔ Contraindications

Hypersensitivity, gastric malignancy.

⚠️ Precautions & Warnings

Gastric carcinoma Impaired, renal impairment, liver impairment.

⚠️ Adverse Reactions / Side Effects

Blood dyscrasias, hypotension, tachycardia, emesis, headache, dizziness, constipation, diarrhoea, nausea, dry mouth, bradycardia, anorexia, cholestatic jaundice, anaphylaxis, angioedema, arthralgia, muscle cramp,renal failure, abnormal liver enzymes, CNS disturbances. Rarely reversible gynaecomastia, toxic epidermalnecrolysis, chest tightness, interstitial pneumonia, paraesthesia, seizures

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:
Avoid unless potential benefit outweighs risk.
Lactation / Breastfeeding:
Not recommended.

📚 Official Regulatory & Clinical References

  • Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
  • World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
  • Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

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