🩺 ANGIOTENSIN-II ANTAGONISTS, COMBINATIONS 🏷️ Angiotensin II antagonis/Calcium antagonist/Thiazide diuretic
👨‍⚕️ Clinically Reviewed by: PakistaniBano Medical Editorial Board (Pharm.D Panel)
📅 Reviewed: November 2026 • 🔍 Authority: DRAP / WHO ATC
📦 Formulations, Pack Sizes & Retail Prices Currency: Rs.
Dosage Form Reg. No Pack Size Trade Price (TP) Maximum Retail Price (MRP)
Tab 5/160/12.5 mg — 2x7 Rs.374.85 Rs.441.00
Tab 5/160/25 mg — 2x7 Rs.317.90 Rs.374.00
Tab 10/160/12.5 mg — 2x7 Rs.435.20 Rs.512.00
Tab 10/160/25 mg — 2x7 Rs.362.95 Rs.427.00

📋 Indications & Clinical Dosage

*Hypertension not adequately controlled by valsartan and amlodipine:* Adults: 1 tab daily using the strength as clinically appropriate. Children: Not recommended.

⛔ Contraindications

Biliary cirrhosis or cholestasis.

⚠️ Precautions & Warnings

Patients with activated renin-angiotensin system that are receiving angiotensin receptor blockers, hepatic impairment or biliary obstructive disorders, aortic or mitral stenosis or obstructive hypertrophic cardiomyopathy, hyperkalaemia.

🔄 Drug Interactions

K supplements, K-sparing diuretics, K-containing salt substitutes or other drugs that may increase K levels (heparin, etc.)

⚠️ Adverse Reactions / Side Effects

Renal impairment, cough, fatigue, GI disturbance, headache, syncope, hypersensitivity reactions, myalgia, neutropenia, pruritus, rash,serum sickness, thrombocytopenia, vasculitis, nasopharyngitis, flu, oedema (pitting, facial, peripheral), flushing, asthenia, hot flush.

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:
Contraindicated in pregnancy.
Lactation / Breastfeeding:
Not recommended.

📚 Official Regulatory & Clinical References

  • Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
  • World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
  • Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

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