📋 Indications & Clinical Dosage
*Metastatic castration-resistant prostate cancer where disease has progressed during or after treatment with a docetaxel-containing chemotherapy regimen (in combination with prednisone or
prednisolone), Metastatic castration-resistant prostate cancer in patients asymptomatic or mildly symptomatic after failure of androgen deprivation therapy (in combination with prednisone or
prednisolone):*
Adult: 1 gm once daily, for dose of concurrent prednisone or prednisolone, consult product literature.
⚠️ Precautions & Warnings
Diabetes, increased risk of hyperglycaemia; monitor blood sugar frequently, history of cardiovascular
Disease. Men should use condoms if their partner is pregnant, and use condoms in combination with another effective contraceptivemethod
if their partner is of child-bearing potential - toxicity
⚠️ Adverse Reactions / Side Effects
Angina pectoris, arrhythmias, bone fracture, diarrhoea, dyspepsia, haematuria, heart failure, hepatic disorders, hypertension,
Hypertriglyceridaemia, hypokalaemia, left ventricular dysfunction, osteoporosis, peripheral oedema, rash, sepsis, urinary tract infection. Rare: Alveolitis allergic, adrenal insufficiency, myopathy, myocardial infarction, QT interval prolongation