📋 Indications & Clinical Dosage
*Chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5, or 6 infection without cirrhousis or with compensated cirrhosis, in combination with ribavirin with decompensated cirrhosis:*
Adult: 400/100 mg once daily for 12 weeks; may extend to 24 weeks if required (consult product literature).
⚠️ Precautions & Warnings
Hepatitis B co-infection, renal impairment, decompensated cirrhosis, patients awaiting liver transplantation. Serious symptomic bradycardia may occur in patients taking amiodarone, particularly in patients also receiving beta blockers, or those with underlying cardiac comorbidities and/or advance liver disease.
🔄 Drug Interactions
Telaprevir, boceprevir, other direct-acting HCV antivirals. Modafinil, potent P-gp inducers
⚠️ Adverse Reactions / Side Effects
Agitation, alopecia, anaemia, anxiety, arthralgia, asthenia, blurred vision, chest pain, constipation, decreased appetite, depression, diarrhoea, dizziness, dry mouth, dyspnea, gastro-oesophageal reflux, abdominal discomfort, headache, influenza-like symptoms, insomnia, irritability, memory impairment, migraine, myalgia, nausea, neutropenia, rash, vomiting, weight loss