📋 Indications & Clinical Dosage
*Community acquired pneumonia, Acute bacterial exacerbations of chronic bronchitis:*
Adults: 400 mg on day 1, followed by 200 mg once daily for 9 days.
*Typhoid & paratyphoid:*
Adult: 200-400 mg daily in two divided doses for 14 days. Children: Not recommended.
⚠️ Precautions & Warnings
Severe hepatic insufficiency, avoid exposure to the sun or ultraviolet light during treatment. Risk factor for QTinterval prolongation; caution advised in conditions such as: Acute myocardial infarction, bradycardia, congenital long QT syndrome, electrolytedisturbances, heartfailure with reduced left ventricular ejection fraction, history ofsymptomatic arrhythmias, epilepsy, history of CNS disorders, severe renal impairment; reduce dose by half. Patients should be well hydrated, patients with G-6-PD defects, Driving or operating machinery.
🔄 Drug Interactions
Antiarrhythmic agents, astemizole,
phenothiazines, tricyclic antidepressants, cisapride, theophylline, cimetidine, sucraltate, magnesium, aluminium or iron salts, anticoagulants, NSAIDs.
⚠️ Adverse Reactions / Side Effects
Anorexia, anxiety, arthralgia, asthenia, blood disorders, GI disturbances. Dizziness, headache, tremor, confusion, convulsions, sleep disorders, rashes, photosensitivity, joint pain, impaired judgment and dexterity transient increase in serum creatinine, haematological, hepatic and renal disorder, tachycardia. Rare: Vasculitis, pseudomembranous colitis,
haemorrhagic bullae, Stevens-Johnson and Lyell syndrome, visual disturbances, transient hearing loss, tenosynovitis, impaired taste, smell and vision
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated
Lactation / Breastfeeding:
Contraindicated