📋 Indications & Clinical Dosage
*Acute bacterial exacerbation of chronic bronchitis:*
ORAL OR BY IV INJ: Adults: 400 mg dailyfor 5 days.
*Acute sinusitis:*
ORAL OR BY IV INJ: Adults: 400 mg dailyfor 10 days.
*Community-acquired pneumonia:*
ORAL OR BY IV INJ: Adults: 400 mg dailyfor 7-14 days.
*Complicated urinary tract infections, Acute pyelonephritis, Skin structure infections:*
ORAL OR BY IV INJ: Adults: 400 mg dailyfor 7-10 days.
*Uncomplicated urinary tract infections (cystitis):*
ORAL OR BY IV INJ: Adults: 400 mg dailyfor 3 days.
*Uncomplicated urethral, cervical or rectal gonor-rhoea:*
ORAL OR BY IV INJ: Adults: 400 mgsingle dose.
💊 Mode of Administration
lnj must be diluted to 2 mg/ml prior to administration. Infuse over 60 min.
⛔ Contraindications
Hypersensitivity to gatifloxacin or other quinolone.
⚠️ Precautions & Warnings
Bradycardia, acute myocardial ischaemia, seizures. Discontinue if significant CNS adverse effects occur. May prolong QT interval, may cause increased CNS stimulation, may exacerbate myasthenia gravis, severe hypersensitivity reactions, including anaphylaxis, serious disruptions in glucose regulation (including hyperglycaemia and severe hypoglycaemia) may occur, generally in patients with diabetes, tendon inflammation and rupture; discontinue at first signs or symptoms of tendon or pain. Prolonged use may result in super infection; pseudomembranous colitis may occur and should be considered in all patients who present with diarrhoea.
🔄 Drug Interactions
Drugs which prolong QT interval, drugs which induce bradycardia, hypoglycaemic agents, insulin, probenecid, loop diuretics, cimetidine (probably other H2 antagonists), digoxin, warfarin, corticosteroids, antacids.
⚠️ Adverse Reactions / Side Effects
Diarrhoea, dizziness, headache, nausea, vomiting, abdominal pain, anorexia, anxiety, arthralgia, asthenia, blood disorders, confusion, depression, disturbances in taste, hearing, smell and vision, dyspepsia, eosinophilia, hallucinations, leucopenia, myalgia, rash, sleep disturbances, thrombocytopenia, tremor. Rare: antibiotic-associated colitis, convulsions, dyspnea, hepatic dysfunction, hepatitis, hypotension, interstitial nephritis, jaundice, photosensitivity, psychoses, renal failure, symptoms of peripheral neuropathy, tendon damage and inflammation, vasculitis, Stevens-Johnson syndrome, toxic epidermal necrolysis
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised
Lactation / Breastfeeding:
Caution advised
🧪 Compatibility & Storage Stability
Compatibility: Stable in D5LR, D5W, D5NS. Incompatible with SWFI.
Stability & Storage: Store at 25C. Do not freeze.